Takayuki Ikezoe Selected Research

Thrombomodulin

12/2021	An evaluation of the Japanese Society on Thrombosis and Hemostasis criteria for disseminated intravascular coagulation as a predictor of prognosis in patients with infection.
2/2021	Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa.
1/2021	Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies.
1/2020	Analysis of the association between resolution of disseminated intravascular coagulation (DIC) and treatment outcomes in post-marketing surveillance of thrombomodulin alpha for DIC with infectious disease and with hematological malignancy by organ failure.
1/2019	Clinical effects of recombinant thrombomodulin and defibrotide on sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation.
12/2017	In vitro studies on the role of recombinant human soluble thrombomodulin in the context of retinoic acid mediated APL differentiation syndrome.
5/2017	The Fifth Epidermal Growth Factor-like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner.
1/2017	The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15.
1/2015	Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation.
7/2014	Pathogenesis of disseminated intravascular coagulation in patients with acute promyelocytic leukemia, and its treatment using recombinant human soluble thrombomodulin.

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Takayuki Ikezoe Research Topics

Disease

37	Neoplasms (Cancer) 01/2022 - 01/2002
33	Leukemia 03/2020 - 05/2002
25	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2022 - 10/2003
17	Disseminated Intravascular Coagulation 06/2022 - 11/2012
12	Prostatic Neoplasms (Prostate Cancer) 09/2007 - 09/2002
8	Thrombosis (Thrombus) 06/2022 - 08/2014
8	Hemorrhage 01/2022 - 06/2011
8	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 03/2021 - 05/2002
8	Acute Promyelocytic Leukemia 12/2017 - 10/2003
7	Hematologic Neoplasms (Hematological Malignancy) 06/2022 - 02/2004
7	Multiple Myeloma 01/2021 - 02/2004
6	Sepsis (Septicemia) 01/2022 - 12/2003
6	Myeloid Leukemia (Leukemia, Myelocytic) 09/2012 - 10/2003
5	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 04/2022 - 08/2014
5	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2021 - 04/2005
4	Primary Myelofibrosis (Myelosclerosis) 01/2021 - 01/2017
4	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 03/2013 - 04/2005
3	Infections 12/2021 - 01/2018
3	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 01/2021 - 01/2018
3	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2019 - 06/2008
3	Fibrosis (Cirrhosis) 11/2017 - 02/2004
3	Fever (Fevers) 01/2015 - 10/2010
3	Lymphoma (Lymphomas) 01/2015 - 05/2002
3	Blast Crisis (Blast Phase) 03/2014 - 10/2006
3	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 12/2013 - 09/2006
3	Breast Neoplasms (Breast Cancer) 08/2010 - 06/2003
3	Hypereosinophilic Syndrome (Loeffler Endocarditis) 08/2010 - 10/2006
3	Carcinogenesis 04/2008 - 09/2002
2	Hemolysis 04/2022 - 06/2018
2	Inflammation (Inflammations) 01/2022 - 01/2017
2	Splenomegaly 01/2022 - 06/2017
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 11/2019
2	Communicable Diseases (Infectious Diseases) 02/2021 - 01/2020
2	Thrombotic Microangiopathies 01/2021 - 01/2019
2	B-Cell Lymphoma (Lymphoma, B Cell) 01/2018 - 12/2009
2	Pancytopenia 11/2017 - 01/2015
2	Thrombocytopenia (Thrombopenia) 01/2017 - 01/2016

Drug/Important Bio-Agent (IBA)

16	Dacarbazine (DIC)FDA LinkGeneric 06/2022 - 11/2012
16	ThrombomodulinIBA 12/2021 - 11/2010
12	Proteins (Proteins, Gene)FDA Link 06/2022 - 02/2004
11	Phosphotransferases (Kinase)IBA 01/2022 - 01/2002
10	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2002
10	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2017 - 06/2003
7	NF-kappa B (NF-kB)IBA 06/2008 - 12/2003
7	herbal preparation PC-SPESIBA 09/2007 - 09/2002
7	AndrogensIBA 09/2007 - 11/2003
6	Cytarabine (Cytosar-U)FDA LinkGeneric 06/2022 - 09/2009
6	CytokinesIBA 01/2022 - 12/2003
6	Aurora Kinase AIBA 01/2021 - 06/2007
5	eculizumab FDA Link 04/2022 - 08/2014
5	Messenger RNA (mRNA)IBA 10/2020 - 06/2003
5	Everolimus FDA Link 03/2013 - 10/2006
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2010 - 06/2008
5	Androgen Receptors (Androgen Receptor)IBA 09/2007 - 11/2003
4	Tyrosine Kinase InhibitorsIBA 03/2021 - 02/2012
4	Imatinib Mesylate (Gleevec)FDA Link 12/2013 - 05/2008
4	Sunitinib (Sutent)FDA Link 02/2012 - 09/2006
4	TOR Serine-Threonine KinasesIBA 08/2010 - 10/2006
4	AZD 6244IBA 07/2010 - 06/2008
4	Human immunodeficiency virus 1 p16 proteaseIBA 08/2006 - 04/2004
3	Histones (Histone)IBA 06/2022 - 01/2015
3	EnzymesIBA 01/2022 - 08/2006
3	AnticoagulantsIBA 01/2022 - 08/2014
3	MLN 8237IBA 01/2021 - 03/2014
3	Interleukin-10 (Interleukin 10)IBA 10/2020 - 03/2013
3	Monoclonal AntibodiesIBA 01/2020 - 09/2015
3	Lenalidomide (CC 5013)FDA Link 12/2018 - 06/2011
3	Calcineurin InhibitorsIBA 01/2018 - 09/2012
3	Epidermal Growth Factor (EGF)IBA 05/2017 - 05/2012
3	Transcription Factors (Transcription Factor)IBA 07/2011 - 05/2002
3	Aurora Kinase BIBA 01/2010 - 09/2007
3	Aurora KinasesIBA 04/2008 - 06/2007
3	Calcitriol (Calcijex)FDA LinkGeneric 08/2006 - 11/2002
3	Ritonavir (Norvir)FDA Link 08/2006 - 04/2004
3	Prostate-Specific Antigen (Semenogelase)IBA 03/2004 - 11/2003
2	HMGB1 Protein (HMG1)IBA 06/2022 - 03/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2021
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2022 - 04/2004
2	Pharmaceutical PreparationsIBA 01/2022 - 10/2004
2	Dasatinib (BMS 354825)FDA Link 03/2021 - 03/2014
2	nilotinib FDA Link 02/2020 - 08/2010
2	AntithrombinsIBA 01/2020 - 01/2020
2	defibrotideIBA 01/2019 - 01/2018
2	SteroidsIBA 11/2017 - 08/2003
2	Small Interfering RNA (siRNA)IBA 04/2017 - 11/2013
2	Cadherins (E-Cadherin)IBA 04/2017 - 02/2004
2	LipopolysaccharidesIBA 01/2017 - 12/2003
2	ChromatinIBA 01/2016 - 01/2015
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 09/2015 - 01/2015
2	STAT5 Transcription FactorIBA 08/2015 - 05/2011
2	Protein CIBA 01/2015 - 05/2012
2	Decitabine FDA Link 03/2014 - 07/2011
2	MethyltransferasesIBA 03/2014 - 07/2011

Therapy/Procedure

13	Therapeutics 01/2022 - 10/2003
10	Drug Therapy (Chemotherapy) 05/2021 - 12/2003
5	Hematopoietic Stem Cell Transplantation 01/2021 - 05/2017
3	Remission Induction 05/2021 - 07/2014
3	Stem Cell Transplantation 01/2021 - 06/2008
2	Transplantation 01/2021 - 01/2020
2	Aftercare (After-Treatment) 11/2017 - 09/2002